<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:27fb4f25-895c-4261-9ad5-0d75d8efcf13,g:f72549e7-e2c8-4fa9-abee-d68ac3a5ae26-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.five9.com/role/CoverPage" xlink:type="simple" xlink:href="fivn-20231102.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.five9.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_85a29fc7-034c-4f2c-81cf-d7aad7bc7b78" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_DocumentType_85a29fc7-034c-4f2c-81cf-d7aad7bc7b78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_f3003308-f469-48ff-b007-bc628fcceb53" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_DocumentPeriodEndDate_f3003308-f469-48ff-b007-bc628fcceb53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_5b1afc75-a3eb-462b-8b5b-2a2e3d7eceb0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityRegistrantName_5b1afc75-a3eb-462b-8b5b-2a2e3d7eceb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_c903d213-92b4-4a5b-845a-693b2e405d55" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityIncorporationStateCountryCode_c903d213-92b4-4a5b-845a-693b2e405d55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_c3f7b2c3-d721-4c65-82c1-daba3c36daef" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityFileNumber_c3f7b2c3-d721-4c65-82c1-daba3c36daef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_26a486df-fc4e-4a87-89b9-9f51cb21e8c1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityTaxIdentificationNumber_26a486df-fc4e-4a87-89b9-9f51cb21e8c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_20b72b32-2e85-45f1-8219-31e2fbe71c12" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityAddressAddressLine1_20b72b32-2e85-45f1-8219-31e2fbe71c12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_0d3754f1-0812-4742-9fdd-f21cb280dd13" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityAddressAddressLine2_0d3754f1-0812-4742-9fdd-f21cb280dd13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_2939c855-6df8-4f99-bca8-50471d874447" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityAddressCityOrTown_2939c855-6df8-4f99-bca8-50471d874447" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_6333539d-9dd9-412e-bfb2-00aae5df6b6d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityAddressStateOrProvince_6333539d-9dd9-412e-bfb2-00aae5df6b6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_30c54229-4354-4c18-97fb-d3b952eeefa1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityAddressPostalZipCode_30c54229-4354-4c18-97fb-d3b952eeefa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_5581066e-7ad0-4bde-a3be-7f865f4b5fa4" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_CityAreaCode_5581066e-7ad0-4bde-a3be-7f865f4b5fa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_f291943d-22d4-4897-818b-10c5ebc964d6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_LocalPhoneNumber_f291943d-22d4-4897-818b-10c5ebc964d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_9ed52657-5e0e-4531-9136-51e0f753c65f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_WrittenCommunications_9ed52657-5e0e-4531-9136-51e0f753c65f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_39ced7a5-7ca7-462d-a64c-349009409434" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_SolicitingMaterial_39ced7a5-7ca7-462d-a64c-349009409434" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_38d74cc3-bf46-4e9c-9c1e-eb13ae37da24" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_PreCommencementTenderOffer_38d74cc3-bf46-4e9c-9c1e-eb13ae37da24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_7e8b10af-3985-456e-9a3b-1de87a230425" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_7e8b10af-3985-456e-9a3b-1de87a230425" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_a27f5d3c-a973-4e66-8ac3-b675bde1e97e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_Security12bTitle_a27f5d3c-a973-4e66-8ac3-b675bde1e97e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_a4789c4a-c751-43c9-94d4-f9fd18095057" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_TradingSymbol_a4789c4a-c751-43c9-94d4-f9fd18095057" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_181c55ed-64ab-43db-b219-245d9d8f3ca3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_SecurityExchangeName_181c55ed-64ab-43db-b219-245d9d8f3ca3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_f1e36c27-f8ba-4311-90d8-ad3ff65e1166" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityEmergingGrowthCompany_f1e36c27-f8ba-4311-90d8-ad3ff65e1166" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_d5fa6991-2f9e-406a-9683-51de80b435c6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_EntityCentralIndexKey_d5fa6991-2f9e-406a-9683-51de80b435c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_683fb394-f814-4538-846a-539863bffa39" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3df245f8-b534-44db-831c-9e51466daf95" xlink:to="loc_dei_AmendmentFlag_683fb394-f814-4538-846a-539863bffa39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
